Abstract
Advanced Integration of Large Language Models for Autonomous Systems and Critical Decision SupportLarge language models (LLMs) have shown transformative potential in autonomous systems and critical decision-making, yet standalone models remain limited in robustness, reliability, and safety assurance when deployed in high-stakes environments. This Research Topic began from the premise that such limitations are better addressed by structured integration of multiple specialized models than by scaling any single one (Guo et al., 2024). We invited work on multi-LLM integration for perception, navigation, and decision-making in robots, drones, and vehicles; on human-robot collaboration; on high-stakes decision support; on verification, uncertainty quantification, and safety assurance; and on real-time adaptation.Seven contributions were accepted, spanning agent generation, orchestration, perception, query translation, automated machine learning, intrusion detection, and governance.Deployment in these settings changes the central question. Performance can no longer be judged by fluency or task accuracy alone; it must also be assessed through grounding, reproducibility, latency, calibration, failure containment, human oversight, and auditability. Across domains, the contributions converge on a common conclusion: dependable autonomy is principally a systems-engineering problem.Reliability emerges not from trusting a single model, but from structuring how models are composed, constrained, checked, and connected to action.Perera et al. challenge the fixed-team assumption of many multi-agent systems. Their Initial Automatic and Dynamic Real-Time Agent Generation mechanisms create specialized agents from evolving conversational context. In the evaluated medical scenario, dynamic generation improved coverage, lexical diversity, and thematic relevance over a static AutoGen configuration, treating system composition itself as an adaptive variable. The same move from fixed programs toward prompt-defined behavior appears in LLM-driven swarm simulations (Jimenez-Romero et al., 2025).1 de Zarz à et al.Zhou and Chan address the complementary problem of reproducibility. Their orchestrator, ORCH, 27 decomposes a problem, gathers analyses from heterogeneous models, and merges them through a 28 deterministic protocol; an optional exponential moving average module adapts routing from historical 29 feedback. Gains are strongest on harder reasoning tasks, but entail substantial latency and cost. Taken 30 together, these studies show that adaptation and determinism are not opposites: agent membership and 31 routing may while interfaces, rules, and aggregation procedures remain explicit and 32 auditable, as in ensemble-and-arbiter designs where inter-model disagreement is measured and routed to 33 human review (Lipianina-Honcharenko et al., 2026). Calboreanu makes the architectural argument most explicit. LATTICE separates planning, execution, and 58 governance so that no component both decides an action and judges compliance; it applies policy-as-code 59 through gated execution, escalates uncertain cases to human operators, and preserves provenance through The next phase should connect these principles into end-to-end assurance cases. It requires interoperable 78 agent-tool contracts, benchmarks covering distribution shift and adversarial faults (Radanliev et al., 2026), 79 selective autonomy with tested fallback behavior, and human-centered studies of explanation and escalation.The central lesson is measured but consequential: LLMs become suitable for autonomous systems and 81 critical decision support not as self-sufficient decision makers, but when embedded within architectures that 82 make uncertainty visible, constrain action, preserve accountability, and retain meaningful human control 83 (Santoni de Sio and van den Hoven, 2018).We thank all contributing authors, reviewers, and the Frontiers editorial team for advancing this 85 interdisciplinary discussion.